這個基因編碼一種激素誘導的轉錄抑制因子。這種基因產物的轉錄抑制可以通過與其他抑制因子的相互作用、參與組蛋白脫乙酰化的蛋白質的募集或通過轉錄激活因子的分離來實現。這個基因的產物含有一個羧基末端結構域，可以與其他共加壓蛋白結合。該結構域還允許與nurd復合物的成員相互作用，nurd復合物是一種核小體重塑蛋白復合物，含有脫乙酰酶活性。此外，這個阻遏物包含幾個rna識別基序，這些基序與類固醇受體rna輔活化子結合；這種結合可以調節結合和非結合類固醇受體的活性。[由RefSeq提供，2008年7月]
This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors. [provided by RefSeq, Jul 2008]